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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, such as the recruitment process and consent, adherence, and the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be valid and reduce bias in results, is also necessary. Too much heterogeneity, however, can cause problems with the design of the trial.

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Legality

Pragmatic Play is renowned for its top-quality games and for providing a superior user experience. Its software can be used on mobile devices and in a variety of languages. It has earned itself the status of one of the most popular casino gaming platforms despite its relative infancy. Wolves is one of the latest games, a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They also provide a useful method of determining the causality between the intervention and its effects. However, they shouldn't be used as a substitute for explanation trials.

The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study that includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.